Additional factors contributing to peptic ulcer formation.
 
Symptoms & History

Physical Findings

Stop & Think

Lab and X-Ray

Differential Diagnosis

The Disease

Treatment

Conclusions

Quiz & Evaluation

Other factors associated with ulcer formation.
  • Cigarette smoking impairs mucosal blood flow and healing.
  • Corticosteroid use impairs healing.
  • Too rapid gastric emptying exposes duodenal mucosa to high acid levels leading to duodenal ulceration.
  • Excessive gastrin secretion such as is seen in Zollinger-Ellison syndrome can lead to multiple ulcers at all levels of the GI tract.
  • COPD leading to a chronic respiratory acidosis.
  • Chronic renal failure.
  • Hyperparathyroidism.
  • Personality and psychological stress.
  • Caffeine and foods that stimulate acid secretion.
The take-home message.
 

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