| Symptoms
& History
Physical
Findings
Stop
& Think
Lab
and X-Ray
Differential
Diagnosis
The
Disease
Treatment
Conclusions
Quiz
& Evaluation |
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Cellular
changes in breast cancer development.
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Loss of cell growth regulation
leading to epithelial hyperplasia and sclerosing adenosis.
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Next comes atypical hyperplasia
with evidence of genetic instability.
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Expression of oncogenes
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c-erb-B2
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Her2/neu
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c-ras and c-myc
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Decreased expression of tumor
supressor genes
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Increased expression of cell
cycle proteins.
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Major chromosomal abnormalities
such as aneuploidy and hyperploidy.
Classification
of breast cancer.
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