| Symptoms
& History
Physical
Findings
Stop
& Think
Lab
and X-Ray
Differential
Diagnosis
The
Disease
Treatment
Conclusions
Quiz
& Evaluation |
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More
about multiple sclerosis
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Pathogenesis not well understood.
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Probably immune destruction
of myelin.
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Experimentally can transmit
disease with stimulated T cells.
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CD4+ cytotoxic T cells are implicated.
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Antibodies are also important
in development of the disease.
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Fifteen fold higher incidence
if there is a first degree relative with MS.
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Association with DR2 extended
haplotype.
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Incidence increases the further
from the equator.
Morphologic
features
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