General
and Systemic Histopathology, C601&C602
Slide 25: Hashimoto's Thyroiditis
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The key feature here
will be the lymphoid aggregates with germinal center formation within the
thyroid tissue itself. In the picture to the left, you can obviously
see the clusters of lymphocytes as well as areas fibrosis giving a lobulated
look to the thyroid in general.
See this slide with the
virtual microscope. |
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This is Hashimoto's
thyroiditis. Note the chronic inflammatory infiltrate and especially the
active lymphoid germinal centers within the gland itself. There is marked
destruction of the gland. In areas of attempted regeneration you will see
enthusiastic and stimulated follicular cells we call Hurthle cells. These
are large, brightly pink stained cells that may or may not be seen to in
direct association with a follicle. KNOW THE ANTIBODIES that we use for diagnosis
in this case. When this disease has run its course, what level of thyroid
function do think will remain? |
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