| Symptoms
& History
Physical
Findings
Stop
& Think
Lab
and X-Ray
Differential
Diagnosis
The
Disease
Treatment
Conclusions
Quiz
& Evaluation |
|
The
importance of HPV
-
Detection of HPV DNA in 85%
of cervical cancers, and 90% of precancerous lesions.
-
High and low risk serotypes
of HPV
-
High risk: 16, 18, 31, 33, 35
-
Low risk: 6, 11, 42-44
-
Cell transformation in tissue
culture studies.
-
HPV DNA becomes integrated into
host genome.
-
HPV oncoprotein E6, of
types 16 and 18, bind to tumor supressor gene p53 and accelerate
its degradation.
-
HPV protein E7 affects
cell cycle regulation through the retinoblastoma gene.
-
Chromosome amplification, specifically
3q, is seen with cervical cancers containing HPV type 16 DNA.
How do CIN
and carcinoma differ?
Back |
|