General
and Systemic Histopathology, C601&C602
Slide 135: Kidney with DIC
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The best bet here is
to look in the small vessels of the cortex, especially the glomeruli for the
diagnostic changes. You're looking for thrombi composed only of protein.
If you see what looks like thrombi with lots of RBC's in them, it's not what
we're looking for.
See this slide with the
virtual microscope.
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With disseminated intravascular
coagulation (DIC), the person experiences "run away" intravascular blood clotting.
This condition never just happens out of the proverbial blue. It is always
a complication of something else that can trigger the clotting system, such
as the leakage of amniotic fluid into the circulatory system in the course
of some obstetrical disaster. As you might expect, there will be small thrombi
in vessels through-out the body. This becomes an ischemic disease on the
cellular level. People bleed with this condition because of the breakdown
of the small vessels and consumption of the clotting agents. Causes are gram
negative sepsis, massive trauma, OB disasters, etc. |
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