Physical Findings

Stop & Think

Lab and X-Ray

Differential Diagnosis

The Disease

Treatment

Conclusions

Quiz & Evaluation

• Waldenstrom macroglobulinemia
• Heavy-chain disease
• Primary or immunocytic-associated amyloidosis
• Solitary plasmacytoma
• Monoclonal gammopathy with other lymphoid neoplasms
• Small monoclonal gamma spikes are not uncommon in people with B cell derived lymphomas.
• Monoclonal gammopathy of undetermined significance
• A number of elderly people will have so called "benign" monoclonal spikes.
• These are typically small, and are not associated with an overt plasma cell dyscrasia.