General and Systemic Histopathology, C601&C602
Slide 19: Acute Erosive Esophagitis
OK, the dilated vessels
are not necessarily part of the inflammatory process. These enlarged vessels
are referred to as esophageal varices and result from increased blood flow.
The increase in blood flow results from increased hepatic portal resistance
and the subsequent development of hepatic portal hypertension (increased
hepatic portal blood pressure). This resulting increased portal blood pressure
leads to a greater flow of blood returning to the systemic venous circulation
by way of the anastomosing vessels in the lower third of the esophagus
as well as those in the rectum. This change in the vascularity of the liver
is a permanent alteration associated with cirrhosis. Cirrhosis results
from the liver's attempts to heal itself in the face of chronic and on
going injury. The result is one of scaring and "botched" nodular regeneration
of the liver lobules. This deranged vascular flow in the liver is one of
the most significant outcomes of cirrhosis.