Look at this, a complete
cross section of a pituitary gland! We want to concentrate on the area
right at the edge of the gland for the infiltration of the histiocytes.
The histiocytic infiltrate
in this case is around the capsule of the gland. It is kind of subtle, and
you may want to check on the histology of the normal gland to appreciate the
difference. The histiocytes do not look particularly aggressive, but they
continue to slowly reproduce and cause organ failure.