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General and Systemic Histopathology, C601&C602
     
    Slide 21: Familial polyposis of colon
    The changes are subtle here.  You really must look at the tissue on the slide before going to the microscope. You will see little areas of thickening of the mucosa and that's about it.  In some areas there may even be a polypoid formation but the earliest changes are not easy to see.

    See this slide with the virtual microscope.

    This is a higher power of the polyp area. You will find there are several polyps on your slide. Here you may see a branching pattern of some of the colonic glands in the region of the polyp as well as the hypercellularity. The colonic glands have irregular shapes and contain many more epithelial cells than is called for. You should have no trouble finding mitotic figures, yet even so, this is not a malignancy. 


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