General
and Systemic Histopathology, C601&C602
Slide 204: Placenta, erythroblastosis fetalis
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This slide includes both a
section of placenta and umbilical cord. Look at it all, but the changes will
be in the placental villi. We’re looking for pigment deposition. It’s iron and
represents the leftovers from the RBC destruction brought about by the immune
hemolytic process. Although this is an example of Rh incompatibility, other
RBC antigens can also give rise to this condition. The key factor is that the
antibody must be small enough to pass through the placenta and into the
child’s circulatory system.
See this slide with the
virtual microscope. |
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Look at the placental villi of
with dark brown pigment; it’s iron. This tells us there’s been RBC hemolysis. |
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