| Symptoms
& History
Physical
Findings
Stop
& Think
Lab
and X-Ray
Differential
Diagnosis
The
Disease
Treatment
Conclusions
Quiz
& Evaluation |
|
What
causes a melanoma to develop?
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Most are sporadic, not part
of a specific familial pattern.
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Solar injury is important, but
not the only factor.
-
Preexisting nevus (dysplastic
nevus?)
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Heredity? No consistent genetic
defect.
-
Chemical carcinogens? Rodent
experiments.
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Genetics of heritable melanoma
syndromes.
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Chromosome 1p36, CMM1 locus.
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Chromosome 9p21, tumor supressor
gene p16.
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Chromosome 12q14, cyclin dependent
kinase CDK4.
So, what about dysplastic
nevi?
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