General
and Systemic Histopathology, C601&C602
Slide 125: Fibrosarcoma of Bone
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There are only a few
small fragments of bone on this slide. It's mostly tumor. Look
in the areas that are most cellular for the features characteristic of
this tumor. Among other things, the degree of collagen production
tells the nature of this malignancy.
See this slide with the
virtual microscope. |
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This is a very anaplastic
lesion, as is the case with many sarcomas. Yes it would very difficult
to tell the origin of this lesion if it weren't on the list of diagnosis.
Note how some cells are spindle shaped and have elongated nuclei, this
is one of the diagnostic tips that this a malignancy of fibroblast origin.
You should see many mitoses and some even with tripolar metaphases. This
tumor can arise in practically any soft tissue and I cannot say for sure
if this one is primary in the bone or metastatic. |
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