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General and Systemic Histopathology, C601&C602
     
    Slide 55: Heart with uremic pericarditis
     
     
    Again, getting yourself oriented on the slide will save lots of time. You're looking for the exudate and inflammatory reaction on the epicardial surface.  You will see some "organization" of the exudate.  That is to say ingrowth of granulation tissue.  But there is still very little in the way of an acute inflammatory reaction.

    See this slide with the virtual microscope.

    This slide shows one of the common problems of renal failure: sterile inflammation of mesothelial surfaces. Evidently the uremic products crystallize on these surfaces and elicit an inflammatory reaction. Pleura, abdominal cavity lining, pericardium and even esophagus are sites of this type of injury. Note the granulation tissue (not granulomas, there is a big difference), in the epicardial fat. The exudate is largely proteinaceous. 


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