- Nuclear atypia and immaturity.
- Changes in nuclear-cytoplasmic ratio.
- Immature cells carried high in epithelial covering.
- Nuclear hyperchromasia.
- Variation in nuclear size.
- Increased numbers of mitoses.
- Koilocytic changes of epithelial cells infected with HPV.
- The perinuclear clearing defines the koilocyte.
- The insert in the above picture shows the PAP smear cytology corresponding to the changes in the tissue section.