In this laboratory we will be looking at examples of diseases that begin as, or principally involve, abnormal activation of the immune system. Clearly, the immune system participates to a degree in all forms of disease, most of the time on behalf of the good guys. Here we will see what can happen when our tissues become the object of interest and destruction by our own immune system. We will see examples of both direct assault and what might be termed "innocent bystander" injury. This would be a good time to review the topic of hypersensitivity and the four major classes of this type of injury. In a most distilled form the categories are:
 

Slide 25, Hashimoto's thyroiditis.	Slide 168, skin with amyloid.	Slide 169, skin with amyloidosis.	Slide 190, Kaposi's sarcoma of skin.
			I'd like to take the quiz now.
Slide 190, Kaposi's sarcoma of skin,	Slide 175, kidney with graft vs host reaction.	Immune System Slide Overview

Mark Braun, MD braunm@indiana.edu
Copyright 1998, the Trustees of Indiana University