General and Systemic Histopathology, C601&C602
    Slide 206: Follicular lymphoma

    Hold this slide up to the light and you’ll have no trouble seeing the nodular aggregations. Even though there is nodularity, there is still uniform effacement of the expected nodal architecture. That is to say, the expected microscopic organization of germinal centers, sinusoids and the like has been completely replaced by the monomorphic growth of the malignant lymphocytes.

    See this slide with the virtual microscope.

    Here you can see the nodular, or follicular-like, arrangement of the malignant lymphocytes. Even though they superficially look like germinal centers, there is no maturation of cells and nothing healthy about the organization

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