General and Systemic Histopathology, C601&C602
    Slide 60: Malignant Lymphoma

    Here you can see the generalized replacement of the lymph node architecture with a diffuse infiltrate of lymphocytes.  OK, maybe you can't tell they are lymphocytes by looking at the picture at the left, but when you use your microscope you'll see them.

    See this slide with the virtual microscope.

    The picture says it all here. Remember to look for cleaved nuclei. Does this slide show a diffuse or nodular pattern? Can you identify the cell type? If not, don't be too worried, even for someone who has had a fellowship in the discipline, it isn't always possible. But I do want you to give it a try. Remember, EFFACEMENT of the nodal architecture.

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