General and Systemic Histopathology, C601&C602
    Slide 69: Liver with Chronic Lymphocytic Leukemia

    Look for the malignant infiltrate in the triads of the liver and in the sinusoids of the spleen.

    See this slide with the virtual microscope.

    The changes here are subtle. You will see an infiltrate of, quite frankly benign looking, lymphocytes in the triads. We call this a "cold infiltrate" because the lymphocytes do not have a "stimulated" appearance and are not there as a response to some inflammatory process. These lymphocytes may lack the classical cytologic features of malignancy, but they are indeed malignant. 

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