General and Systemic Histopathology, C601&C602
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Look for the malignant
infiltrate in the triads of the liver and in the sinusoids of the spleen. See this slide with the virtual microscope. |
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The changes here are subtle. You will see an infiltrate of, quite frankly benign looking, lymphocytes in the triads. We call this a "cold infiltrate" because the lymphocytes do not have a "stimulated" appearance and are not there as a response to some inflammatory process. These lymphocytes may lack the classical cytologic features of malignancy, but they are indeed malignant. |