General and Systemic Histopathology, C601&C602
    Slide 84: Lymph Node with Reactive Hyperplasia

    Please observe here that the lymph node is essentially intact.  You can easily see the capsule and the other elements of a healthy lymph node.  You will, however see, considerable reactive hyperplasia of the follicles.

    See this slide with the virtual microscope.

    This node has the classical features of follicular hyperplasia. You will see many large and to some extent odd shaped germinal centers. These changes are reactive, not neoplastic, even though the germinal centers are distorted and look fairly wild. All the cells that should be present are here, and there is NOT a monomorphic pattern or infiltrate. You will see the sinuses are open, and there is no EFFACEMENT of the nodal architecture. This is a reactive and not malignant lymph node.

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