General and Systemic Histopathology, C601&C602
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Here the region of the
tumor is pretty obvious. Look to see how it is spreading at the lateral
and deep margins. If we assume no node or distant metastasis what would
the Dukes classification of this lesion be? What of the TMN classification? See this slide with the virtual microscope. |
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This is a fairly high power view of the cancer with normal tissue at the edges. On low power, you should be able to readily spot the different types of mucosa. In the area of the cancer, observe the "branching and arborizing" gland margins as well as the "gland within gland" pattern of the malignant cells. See what we mean by "nuclear atypia" of the epithelial cells. They are hyperchromatic with irregular nuclear staining and "angulated" nuclear margins. Mitoses are every place. Note the spread into the lamina propria of the malignant cells. Can you think of conditions that are associated with an increased incidence of this condition? |