Physical Findings

Stop & Think

Lab and X-Ray

Differential Diagnosis

The Disease

Treatment

Conclusions

Quiz & Evaluation

• Bimodal distribution. Young adults and older people.
• Malignant cell is the Reed-Sternberg cell.
• The RS cell must be seen in its proper background.
• Reactive lymphocytes and macrophages
• Plasma cells
• Eosinophils
• The background is a benign response to the RS cell.
• Three major histologic types and one controversial one.
• Nodular sclerosing
• Mixed cellularity
• Lymphocyte predominance
• Lymphocyte depletion (may not be HD)
• Staging is critical to therapy selection and outcome.
• Presence (B) or absence (A) of constitutional symptoms is important in staging and predicting outcome.
• Sometimes we get a little punchy. Try out these for a laugh .