General
and Systemic Histopathology, C601&C602
Slide 133: Kidney with diabetic nephropathy
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Even here you can see
the differential staining of the tissue that reflects the extensive glycogen
accumulation within the tubular epithelial cells.
See this slide with the
virtual microscope.
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This slide shows an unusual
change and at the same time one that is very common for diabetics. The
vacuolization of the tubular cells is uncommon and reflects the tubular
cell's attempts to recapture the sugar cleared in the urine. The material
in these cells is glycogen. The glomerular changes are very common. Note
the irregular thickening of the basement membrane of the glomeruli and
the hyalinized and thickened walls of both the afferent and efferent arterioles.
What is the name given to these changes? You will also see some coexisting
larger vascular disease and chronic pyelonephritis. |
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