General and Systemic Histopathology, C601&C602
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Even here you can see
the differential staining of the tissue that reflects the extensive glycogen
accumulation within the tubular epithelial cells. See this slide with the virtual microscope. |
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This slide shows an unusual change and at the same time one that is very common for diabetics. The vacuolization of the tubular cells is uncommon and reflects the tubular cell's attempts to recapture the sugar cleared in the urine. The material in these cells is glycogen. The glomerular changes are very common. Note the irregular thickening of the basement membrane of the glomeruli and the hyalinized and thickened walls of both the afferent and efferent arterioles. What is the name given to these changes? You will also see some coexisting larger vascular disease and chronic pyelonephritis. |