General and Systemic Histopathology, C601&C602
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This section of prostate
includes both areas of hyperplasia and malignancy. The adenocarcinoma should
be obvious. Look for the bluer areas. Note the lobulation. You want to identify
the capsule and scan around it looking for capsular invasion and perineural
involvement. See this slide with the virtual microscope. |
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This section nicely
shows the famous “gland-within-gland” pattern of the adenocarcinoma. The
insert shows the cellular detail from the edge of one of these malignant
gland forms. Note the angulation of the nuclear membranes and prominent nucleoli.
Be sure to check the capsule of the gland for invasion and pay attention to the little nerves in the surrounding fat. I don’t recall seeing perineural invasion, but it might be present on your slide. What about PSA? Would you expect it elevated in this case? |