General and Systemic Histopathology, C601&C602
    Slide 87: Squamous Cell Carcinoma of Skin
    Here you can see the malignancy in the center of the skin biopsy.  Please take the time to look at the surrounding skin first.  You will see there is rather significant solar damage to the dermal connective tissue and very likely there will be dysplasia of the epithelial covering as well. 

    See this slide with the virtual microscope.

    You will see groups and clusters of malignant squamous epithelial cells extending into the dermis, and many reveal whirl like clusters of desquamated squamous cells centrally. Some of these groups have areas of necrosis, and you will see a mixed acute and chronic inflammatory infiltrate in many areas. 

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