General and Systemic Histopathology, C601&C602
    Slide 157: Skin with recurrent squamous cell carcinoma
    Here you see the groups of malignant cells within the dermis but seemingly having no connection to the epidermis.  What's the explanation?

    See this slide with the virtual microscope.

    The picture of this slide could be in focus a little better, but it's what we have. Note the epithelium does not show changes of nuclear atypia nor cancer. The squamous cancer is in the dermis, and represents a recurrence from a previously removed malignancy. On your slide, you should be able to see the hallmark nuclear features of cancer i.e. angulated nuclear margins, hyperchromasia and reduced nuclear to cytoplasmic ratio. Look for "intracellular" bridges between the malignant cells.

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