General and Systemic Histopathology, C601&C602
    Slide 17: Skin with leishmaniasis.
    This specimen consists of little fragments of skin and it's difficult to get oriented. You want to be looking in the dermis for histiocytes containing the organisms.  There is a lot of necrosis along with the inflammatory infiltrate.

    See this slide with the virtual microscope.

    This slide is not H&E stained. We used a stain to highlight the organisms. In some slides there is an ulcer with granulation tissue in the base. Look in the dermis and you will see an infiltrate composed largely of mononuclear cells. The organisms are in the monocytes, and appear as small dots with a cleared area or "halo" around them. They are quite small. Some may appear in the tissue, but I think this reflects rupture of the cells, possibly even as a tissue processing artifact. This slide is to further your education, and I'll tell you right now I don't have a sample of this in my quiz slide collection.

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