Physical Findings

Stop & Think

Lab and X-Ray

Differential Diagnosis

The Disease

Treatment

Conclusions

Quiz & Evaluation

• People with high LDL and low HDL cholesterol levels have an increased risk for atherosclerosis.
• Genetic defects of lipoprotein metabolism are known to increase risk of atherosclerosis.
• Hypercholesterolemia may cause endothelial cell dysfunction.
• Oxidation of LDL by free radicals generated by macrophages and monocytes
• serves as chemotactin for circulating monocytes,
• increases monocyte adhesion, 
• stimulates release of growth factors and cytokines,
• cytotoxic to endothelial cells,
• is immunogenic leading to the production of antibodies.