Physical Findings

Stop & Think

Lab and X-Ray

Differential Diagnosis

The Disease

Treatment

Conclusions

Quiz & Evaluation

• H. pylori elaborates a platelet activating factor that causes thrombotic occlusion of the superficial capillaries of the mucosa, thereby leading to ischemic injury.
• Colonization of the mucosa leads to chronic inflammation which enhances susceptibility to acid injury.
• The damaged mucosa leaks micronutrients onto its surface, thereby creating a local environment favorable to H. pylori.
• The free ammonia elaborated by the bacteria is thought to stimulate the release of gastrin, leading excessive acid production (a feature considered of importance in the formation of duodenal ulcers).

• Non-steroidal anti-inflammatory drugs suppress the prostaglandin synthesis, thereby interfering with healing.