| Symptoms
& History
Physical
Findings
Stop
& Think
Lab
and X-Ray
Differential
Diagnosis
The
Disease
Treatment
Conclusions
Quiz
& Evaluation
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HIV-1 Life Cycle
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Single stranded RNA retrovirus.
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The envelope glycoprotein (gp120),
attaches to the CD4 receptor of the T-lymphocyte.
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The nucleic acid core of the
virus enters the cell with help of the gp41 viral surface protein.
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Reverse transcriptase creates
a double stranded DNA copy of the viral genome
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The newly created viral DNA
is incorporated into the host cell genome by means of an endonuclease.
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Transcription of viral genes
now proceeds and the cell begins making new viral core particles, structural
and assembly proteins.
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The viral cores migrate to areas
of the host cell membrane containing gp120 and gp41 viral specific glycoproteins.
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New viruses assemble and bud
from the host cell membrane.
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Life cycle
diagram.
The pathophysiology
of the infection.
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