| Symptoms
& History
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Findings
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& Think
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and X-Ray
Differential
Diagnosis
The
Disease
Treatment
Conclusions
Quiz
& Evaluation
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The Course of Events of the
Infected CD4+ Cells
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Following initial incorporation
into the host cell genome, the viral DNA remains inactive.
New virus production begins
when the infected host cell is
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activated by exposure to an
antigen, or
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stimulated by a cytokine
For an AIDS patient during
the period of active infection,
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Approximately 100 billion new
viruses are made each day.
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1 to 2 billion CD4+ T cells
die each day.
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CD4+ T cell production proceeds,
but cannot keep up with loss of the viral infected cells
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Loss of "memory" T cells early
in the course of the illness substantially effects the patient's response
to various classes of infectious agents.
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Infected macrophages appear
less susceptible to cytopathic effects of the HIV virus, although macrophages
make large numbers of the virus particles
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