General and Systemic Histopathology, C601&C602
    Slide 165: Bone marrow with cryptococcus infection
    This is a small core biopsy of bone which shows only minimal replacement of the bone marrow space with an inflammatory infiltrate.  It takes the special stain to show the organisms.  Obviously, the history was very important in knowing what to do to make the diagnosis in this case.

    See this slide with the virtual microscope.

    This is one of two slides of the same tissue. This is H&E stained, and does not show the organism. You will see a fairly "bland" infiltrate diffusely throughout the marrow composed of monocytes. Additionally, there is an overall depression of the number of myeloid precursors present. These two factors, coupled with the history are significant elements in leading the pathologist to the next move, which will lead to the diagnosis. For the definitive findings, look at slide 166, which is stained using a silver salt procedure. Here the organisms can be identified. 

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