General and Systemic Histopathology, C601&C602
Diseases of the Musculoskeletal System
Disorders of the musculoskeletal system cut a wide path across all categories and types of injury. For example vascular and neurological conditions can directly affect muscular activity and strength. Moreover, it's often difficult, at least initially, to distinguish underlying causes of progressive muscular weakness, and occasionally a muscle or even peripheral nerve biopsy is called for. In other situations, serum antibody studies prove helpful in making a particular diagnosis. But always, the diagnostic process begins with the history and physical exam.
In this unit we will
be looking at a number of categories of disease with either primary or significant
secondary effects on the muscular system, bone and/or connective tissue.
In some situations the causation may be straight forward, whereas in others
the mechanism of injury and development of the disease will be baffling.
A case in point is myositis ossificans. Here we will see an example of fully
developed benign bone forming at a site of injury either in soft tissue or
skeletal muscle. Very peculiar. We will also study examples of primary inflammatory
states, as well as malignancies, of the skeletal muscle and soft tissues.
Even though we may not review a case of every type of injury or disease, remember
the musculoskeletal system can suffer from each of the major divisions of
injury. Here are a few that are representative of all.
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