The skin is a much more complex organ than most people think, and this includes many physicians. It's involvement in normal physiology goes far beyond just holding us together and serving as a barrier to the outside world. Obviously it's involved in temperature regulation, fluid and electrolyte balance (at least secondarily), antigen processing and even vitamin metabolism. Because it is one of our principal points of contact with the outside world, it is subject to many environmental stresses. These stresses may produce fairly diagnostic changes or in some cases outright diseases. We will look at a number of lesions as well as ways in which the skin tries to adapt to changing environmental influences. Principal among these is solar induced injury, and resultant skin malignancies. But we must keep in mind that the skin will also reflect underlying, and often quite distant, medical problems. We will see examples of metastatic cancer to the skin, as well as immunologic and infectious injury. Although our collection may be somewhat limited, we will look at representative examples of most forms of injury of the skin, and you should be able to apply what you learn to most other cutaneous disorders. Hang in there.
   

Slide 17, skin with leishmaniasis.	Slide 31, breast skin with Paget's disease.	Slide 31, breast skin with Paget's disease, a higher power view.	Slide 33, skin with metastatic breast cancer in the dermis.	Slide 52, skin with intradermal nevus.	Slide 65, ruptured epidermal inclusion cyst of the skin.
Slide 87, squamous cell carcinoma of skin.	Slide 87, squamous cell carcinoma of skin, a higher power view.	Slide 93, basal cell carcinoma of skin, a scanning power view.	Slide 93, basal cell carcinoma of skin, a medium power view.	Slide 93, basal cell carcinoma of skin, a high power view	Slide 116, skin with malignant melanoma.
Slide 116, malignant melanoma of skin.	Slide 118, lymph node with metastatic malignant melanoma.	Slide 150, skin with intradermal nevus.	Slide 151, seborrheic keratosis of skin.	Slide 152, epidermal inclusion cyst of the skin.	Slide 154, keratoacanthoma of the skin.
Slide 156, dermatofibrosarcoma protruberans of skin.	Slide 157, skin with recurrent squamous cell carcinoma.	Slide 168, skin with amyloid. Hematoxylin-eosin stain.	Slide 169, skin with amyloidosis.	Slide 185, molluscum contagiosum of skin.	Slide 186, verruca vulgaris (wart) of skin.
					I'd like to take the quiz now.
Slide 190, Kaposi's sarcoma of skin.	Slide 190, Kaposi's sarcoma of skin, a higher power view.	Normal skin		Dermpath Slide Overview

Mark Braun, MD braunm@indiana.edu
Copyright 1998, the Trustees of Indiana University