General
and Systemic Histopathology, C601&C602
Slide 116: Skin with malignant melanoma
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Although this is just
a little shave biopsy of skin, you can easily see the central area of thickening
where the melanoma is.
See this slide with the
virtual microscope.
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The skin in this slide
shows clusters of malignant melanocytes in the dermis. Observe the lack
of "cohesion" of the cells. Nuclear features of malignancy should be obvious,
and many cells will show abundant pigment. There is no "maturation
from surface to base" in this lesion, an important consideration in
distinguishing this from its benign counterpart, a "nevus." Depth of penetration
is a critical part of "staging" this lesion. |
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