General
and Systemic Histopathology, C601&C602
Slide 31: Breast Skin with Paget's Disease
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Here we have the condition
of malignant duct cells growing up the major excretory ducts of the breast
and out into the epithelial covering of the skin. You will actually
see clusters of malignant cells in the epithelium itself. Look down
in the breast to confirm the malignancy first. Sometimes this can
be confused microscopically with an early amelanotic melanoma. Grossly,
this lesion is red and crusted and looks like a little focus of irritation
on the nipple or areola.
See this slide with the
virtual microscope. |
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In this and the next
slide, you will see clusters of the malignant ductal epithelial cells actually
within the epithelial covering of the skin. These cells may look a bit like
non-pigmented malignant melanocytes, but they are indeed from the breast ducts.
They have "migrated" along the basement membrane of the major breast ducts
to end up in the skin. The cells you see here are not within dermal lymphatics,
but rather the actual epithelial surface of the breast itself. |
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