Physical Findings

Stop & Think

Lab and X-Ray

Differential Diagnosis

The Disease

Treatment

Conclusions

Quiz & Evaluation

• A third will die of the disease
• Rare before 25, but incidence rises with age.
• Average age at diagnosis is 64.
• Genetic predisposition
• Familial history is a risk factor
• BRCA1 and BRCA2 genes account for 5-10%
• Increased risk associated with cancer of the contralateral breast and/or endometrium.
• Radiation exposure increases risk.
• Geography and/or ethnic background is important. Asian women have reduced risk, but rises slowly after immigrating to the west.
• Risk increases with early menarche and late menopause.
• More frequent in nulliparous women as compared to multiparous women.
• Increased risk in women older than 30 years at the time of their first child.
• Post menopausal estrogens and oral contraceptives have little if any effect on incidence.