| Symptoms
& History
Physical
Findings
Stop
& Think
Lab
and X-Ray
Differential
Diagnosis
The
Disease
Treatment
Conclusions
Quiz
& Evaluation |
|
When
distant metastasis are present, cure is unlikely.
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Long term remissions
are possible, especially in hormonally responsive tumors.
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Lymph node metastasis:
most important prognostic factor.
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No involvement = 70% to 80%
10-yr survival.
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One to three nodes = 35% to
40% 10-yr survival
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Locally advanced disease:
Skin, fascia or muscle involvement are often associated with distant metastasis.
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Tumor size: the
smaller the lesion the better.
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< 1 cm = 98% 5 yr survival
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< 2 cm and no nodes = 96%
5-yr survival
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Histology: the
less well differentiated the tumor, the poorer the prognosis. Mitotic rate
is very important in grading.
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ERA/PRA status:
cancers with high levels of hormone receptors have a slightly overall
better prognosis than those without receptors.
More prognostic
factors
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