| Symptoms
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Cholelithiasis
Hereditary
factors above and beyond ethnicity, so called lith genes.
-
Impaired
bile salt synthesis and excretion (can't keep cholesterol in soluble
form).
-
Increased
serum and biliary levels of cholesterol.
Cholesterol Stone
Formation
-
Bile becomes
supersaturated
with cholesterol.
-
Hypomotility
of gallbladder promotes "nucleation."
-
Mucus
hypersecretion in the gallbladder traps the cholesterol crystals,
allowing aggregation into a stone.
Cholesterolosis
of the gallbladder wall is another feature of high cholesterol levels and
something that may play a role in stone formation.
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