General and Systemic Histopathology, C601&C602
    Slide 76: Lung with tuberculosis
    Look carefully at the lung tissue for the little pink areas of caseous necrosis. These are the areas of tubercular infection. They don't show a well developed granuloma architecture, but you'll see the evolving features and should have no trouble finding the giant cells.

    See this slide with the virtual microscope.

    This section of lung is largely replaced with a single granuloma. Note the structure of the granuloma and the fact that it has a "caseous" center. There are numerous giant cells and the fibrous margin of the granuloma is only partially formed at this time. The caseous center of the granuloma is very characteristic of TB. The granuloma itself, and the giant cells, represent a general reaction to an agent the body cannot eliminate or destroy. 


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