and Systemic Histopathology, C601&C602
Slide 165: Bone marrow with cryptococcus
||This is a small core
biopsy of bone which shows only minimal replacement of the bone marrow
space with an inflammatory infiltrate. It takes the special stain
to show the organisms. Obviously, the history was very important
in knowing what to do make the diagnosis in this case.
See this slide with the
||This is one of two slides
of the same tissue. This is H&E stained, and does not show the organism.
You will see a fairly "bland" infiltrate diffusely throughout the marrow
composed of monocytes. Additionally, there is an overall depression of
the number of myeloid precursors present. These two factors, coupled with
the history are significant elements in leading the pathologist to the
next move, which will lead to the diagnosis. For the definitive findings,
look at slide 166, which is stained using a
silver salt procedure. Here the organisms can be identified.