General and Systemic Histopathology, C601&C602
    Slide 9: Stomach with gastric ulcer.
    This picture actually represents about half of the tissue on your slide.  Just imagine it's got a mirror image right half and you'll have it. The photomicrograph below comes from the edge where the ulcer meets the mucosa.  Note the bright pink layer of fibrin and digested protein material that lines the ulcer base. The granulation tissue begins just beneath this. See how the ulcer has eroded completely through the muscle and is about to perforate through the serosal fat.  What do think is the significance of the what is seen just to the left of the ulcer base?

    See this slide with the virtual microscope.

    Your slide includes only about half the ulcer. Before going to the microscope, hold the slide up to the light or look at it on a white background. You should be able to easily spot the area of the ulcer. Try to get yourself oriented before diving in with the scope. Observe the "granulation tissue" in the ulcer base and be sure you can identify angioblasts and the numerous reactive fibroblasts. There is considerable digested debris on the surface of the ulcer, don't confuse this for the reparative elements of granulation tissue. The digested junk contains epithelial cells, inflammatory elements, bacteria and who knows what all. What's the bacterial agent of such renown in this disease? 

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