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General and Systemic Histopathology, C601&C602
     
    Slide 69: Liver with chronic lymphocytic leukemia
     
     
    Can't really see much at this power of magnification.  Look in the triads for the lymphocytic infiltrate.

    See this slide with the virtual microscope.

    The changes here are subtle. You will see an infiltrate of, quite frankly benign looking, lymphocytes in the triads. We call this a "cold infiltrate" because the lymphocytes do not have a "stimulated" appearance and are not there as a response to some inflammatory process. These lymphocytes may lack the classical cytologic features of malignancy, but they are indeed malignant. 


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