As we will see in this unit, the liver is subject to many types of injury. Additionally, many systemic diseases have a liver component and sometimes it's hard to know what might have started a particular pathological condition. We will be studying examples of infectious, vascular, nutritional, obstructive, neoplastic and iatrogenic injury of the liver. It's going to be very important to know the micro architecture of the liver.

The liver is an organ that has a remarkable capacity for regeneration, assuming the underlying reticular (lobular) framework is intact. Unfortunately, in the case of chronic and ongoing injury, complicated by loss of the basic reticular architecture, the drive to repair substantially misses the mark. In this connection, we are going to look at a number of examples and causes of cirrhosis and it's long-term complications. Additionally, the study of hepatitis is going to be very important, but don't make the mistake of thinking that all cases of hepatitis are viral in nature, or for that matter have a microbiological etiology. Many medications cause liver cell injury that can lead to overt hepatitis. And, as I am sure everyone knows, ethanol has rather marked liver toxic properties. One of the leading causes of acute hepatitis is acute alcohol injury. We will see others as well.

As with all of the laboratory units in this course, we are not able to look at examples of every disease of the an organ system. We don't have the time nor is it necessary. Still, the cases presented here should give you a good overview of the major processes and probable outcomes of most forms of liver, gallbladder and pancreatic injury. Good luck.
 

Slide 4, fatty metamorphosis of the liver.	Slide 4, fatty metamorphosis of the liver.	Slide 27, gallbladder with acute and chronic inflammation .	Slide 29, liver with adenoma.	Slide 29, liver with adenoma, a higher power view.	Slide 40, liver with acute yellow atrophy.
Slide 41, liver with acute and chronic cholangitis and fibrosis.	Slide 42, liver with cirrhosis.	Slide 45, post necrotic cirrhosis of liver.	Slide 46, liver with necrosis and cirrhosis.	Slide 47, liver with metastatic carcinoma.	Slide 63, liver with hepatocellular carcinoma.
Slide 63, liver with hepatocellular carcinoma.	Slide 69, liver with chronic lymphocytic leukemia.	Slide 71, liver with hemangioma.	Slide 75, fatty infiltration of pancreas.	Slide 92, pancreas with chronic inflammation and fibrosis.	Slide 92, liver with cirrhosis.
Slide 103, gallbladder with primary adenocarcinoma	Slide 115, liver with biliary obstruction secondary to pancreatic cancer.	Slide 115, liver with biliary obstruction secondary to pancreatic cancer	Slide 117, liver with glycogen vacuoles in nucleus.	Slide 126, gallbladder with acute and chronic cholecystitis.	Slide 132, liver with acute hepatitis.
					I'd like to take the quiz now.
Slide 137, gallbladder with cholesterolosis.	Normal liver	Normal Gallbladder	Normal pancreas	Liver and Pancreas Disease Slides Overview

 

Mark Braun, MD braunm@indiana.edu
Copyright 1998, the Trustees of Indiana University