General
and Systemic Histopathology, C601&C602
Slide 132: Acute viral hepatitis
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There are a number
of features we look for to make the diagnosis of acute hepatitis, and this
slide has them all. Note the "piecemeal (focal ) necrosis" of the hepatocytes
in the lobules. You will see little clusters of acute inflammatory cells
in the lobules and in the triads. There may be some disruption of the "limiting
plate" of the triads too. The limiting plate refers to the junctional zone
(i.e. first layer of hepatocytes) between the triad and the liver lobules.
You should also see some Kupffer cell hyperplasia, again a common finding
in hepatitis, especially viral hepatitis. What exactly are the Kupffer cells
and what do they do? Hint: think reticuloendothelial system.
See this slide with the
virtual microscope.
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