General
and Systemic Histopathology, C601&C602
Slide 69: Liver with Chronic Lymphocytic
Leukemia
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Look for the malignant
infiltrate in the triads of the liver and in the sinusoids of the spleen.
See this slide with the
virtual microscope. |
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The changes here are
subtle. You will see an infiltrate of, quite frankly benign looking, lymphocytes
in the triads. We call this a "cold infiltrate" because the lymphocytes do
not have a "stimulated" appearance and are not there as a response to some
inflammatory process. These lymphocytes may lack the classical cytologic features
of malignancy, but they are indeed malignant. |
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