Physical Findings

Stop & Think

Lab and X-Ray

Differential Diagnosis

The Disease

Treatment

Conclusions

Quiz & Evaluation

• Primarily a disease of young adults, but does have a bimodal distribution.
• A second peak in incidence is seen around 60.
• Differs from non-Hodgkin lymphomas in several ways.
• HD arises in a single lymph node or chain of nodes.
• Spreads to contiguous nodes.
• Characteristic cell is the Reed-Sternberg (RS) cell.
• The RS cell induces the accumulation of reactive cells.
• lymphocytes
• histocytes
• granulocytes and eosinophils
• The RS cell comprises only a small fraction of the tumor bulk (1-5%).
• The cell of origin of the RS cell remains unclear.