Physical Findings

Stop & Think

Lab and X-Ray

Differential Diagnosis

The Disease

Treatment

Conclusions

Quiz & Evaluation

• Even though the Reed-Sternberg cell must be present, and the proper background, not all Hodgkin Disease are alike.
• The chronic inflammatory background induced by the Reed-Sternberg cell may give rise to fibrosis .
• The different mixture of background inflammatory cells, degrees of fibrosis and types of Reed-Sternberg cells produce different histologic classes and clinical outcomes.
• The four basic histologic classes of HD are:
• Nodular Sclerosing
• Mixed Cellularity
• Lymphocyte Predominance
• Lymphocyte Depletion