General and Systemic Histopathology, C601&C602
    Slide 101: Squamous cell carcinoma of lung
    Very little alveolar lung is to be found on this slide.  The tumor has pretty much replaced everything in the region of the sample.  Note how the tumor surrounds and encases the fragments of bronchial cartilage.

    See this slide with the virtual microscope.

    This slide shows a typical squamous cell carcinoma of the lung. Mitotic figures will be common and some "tripolar" mitoses might be present. You should be able to spot the "intercellular bridges" (as opposed to the Madison County type) that characterize squamous cell malignancies. You will see great variation in size of cells and nuclei, but the basics of malignant nuclear features are all here: nuclear/cytoplasmic ratio, angulated nuclear margins and nuclear hyperchromasia. The type of epithelium that gave rise to this malignancy is not normally found in the lung, where do you think it came from?

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