General
and Systemic Histopathology, C601&C602
Slide 80: Lung with metastatic renal
cell carcinoma, clear cell pattern
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The appearance of this
malignancy is a little atypical. Generally the metastases pretty
faithfully reproduce the histological pattern of the primary lesion.
Renal cell is probably the one tumor that most consistently breaks this
rule. Here we see two patterns in the same metastatic focus; a spindle
pattern and the more typical clear cell pattern.
See this slide with the
virtual microscope.
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This slide shows lung
tissue that is essentially replaced with metastatic renal cell carcinoma.
You will see clusters of cells with very clear, washed out
appearing, cytoplasm. The cells appear in clusters that mimic the configuration
of a renal tubule. The cells are clear because the lipid they once contained
was "washed out" by the xylene during the processing of the tissue in preparation
for sectioning. |
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